Induction of microsomal enzymes by this drug, may possibly shorten the 50 percent-life of doxycycline for so long as 2 weeks after barbiturate therapy discontinued; observe medical response to doxycycline intently if both of those drugs administered concurrently
pentobarbital will reduce the level or impact of dapsone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.
Caution when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone might boost and may result in most likely fatal respiratory despair
fentanyl intranasal and pentobarbital each enhance sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom substitute treatment method alternatives are inadequate
pentobarbital will lower the extent or effect of bedaquiline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Prevent coadministration of bedaquiline with strong CYP3A4 inducers as a result of opportunity for lessened therapeutic impact
pentobarbital will lower the extent or influence of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or result of sufentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.
pentobarbital decreases amounts of amphotericin B deoxycholate by inhibition of GI absorption. Applies only to oral form of equally brokers. Minor/Significance Mysterious.
Choices regarding the timing of any elective treatments necessitating anesthesia must choose into account the main advantages of the procedure weighed against the potential risks
Reserve concomitant prescribing of such drugs in patients for read more whom other remedy possibilities are inadequate. Limit dosages and durations towards the least expected. Keep an eye on carefully for signs of respiratory despair and sedation.
fentanyl transmucosal and pentobarbital both increase sedation. Steer clear of or Use Alternate Drug. Restrict use to people for whom choice treatment method choices are inadequate
buprenorphine subdermal implant and pentobarbital both increase sedation. Avoid or Use Alternate Drug. Restrict use to people for whom substitute treatment method possibilities are insufficient
Untimely infants are notably vulnerable to the depressant effects of barbiturates; if barbiturates are employed for the duration of labor and delivery, resuscitation devices must be available
pentobarbital will lower the level or result of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.